To add a printer in PrusaSlicer you have to go to the “Printer Settings” tab, open the “System Settings window” of the default printer and then click on “Add/Remove Printers”.
To add a 3D printer in PrusaSlicer, follow the steps below:
1. Open PrusaSlicer on your computer.
If you don't have PrusaSlicer installed on your computer yet you can check this post «PrusaSlicer: The laminator from Prusa Research»

2. Go to the “Printer Settings” tab

3. Open the “System Settings” Window
And then click on «Add/Remove Printers«

4. Click on other brands.
If your printer is from another brand, click on "other brands"

5. Choose the brand of your 3D printer
Choose the brand of your 3D printer and click "Next"

6. Choose the 3D printer model
I'm going to choose a Creality Ender 3 with a 0.4mm nozzle
After choosing your model, click “next”.

7. Custom settings
In the event that your 3D printer is not on any list, this is where you can put its name and configure it manually.
If you have already chosen your printer from the list then click “next”.

8. Selection of filament profiles.
Here you can configure the filaments that you are going to use.
In my case I am going to choose all the generic options.

9. Automatic updates.
Select both options for the PrusaSlicer program to update automatically.
Click “next”.

10. Reload from disk
According to the official PrusaSlicer page, this function is for when you want to replace the newer version of a model with the older version, without having to reconfigure things like custom supports for example.
you can read more here.
I'm going to leave it disabled. Click “next”.
11. File Association.
Checking these boxes will leave the .3mf and .STL files associated with PrusaSlicer.
This means that every time you double-click on a file, PrusaSlicer will open automatically.
If you use another slicer, don't select them.
Click “Next”.

12. View Mode
If you are a beginner user you can leave the “simple mode” selected. This mode will be basic and without many settings to be modified.
If, on the other hand, you are a more advanced user, select the "Advanced mode" to have better control of all the settings and parameters.
Click Finish.

13. Check that your 3D printer has been added.
Yours should appear in the same printer profile window.

14. Check the Platform tab.
In the platform tab you should see the plate with the brand or logo of your 3D printer

If everything went well, your 3D printer will already be added in PrusaSlicer.
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